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Meta-Analysis of Anti-Muscarinic Receptor Type 3 Antibodies for the Diagnosis of Sjögren Syndrome

Author

Listed:
  • Chuiwen Deng
  • Chaojun Hu
  • Si Chen
  • Jing Li
  • Xiaoting Wen
  • Ziyan Wu
  • Yuan Li
  • Fengchun Zhang
  • Yongzhe Li

Abstract

Purpose: To conduct a meta-analysis to evaluate the diagnostic value of anti-muscarinic receptor type 3 (M3R) antibodies in Sjögren syndrome (SS). Methods: Two databases, PUBMED and the Cochrane Library, were systematically searched. Approximately 2,000 participants from several studies were included in this research. STATA 11.2 software and Meta-DiSc 1.4 was used to conduct the meta-analysis. Results: Eleven studies were included in the meta-analysis. The pooled DOR was 13.00 (95% CI, 6.00–26.00). The sensitivity was 0.43 (95% CI, 0.28–0.58) and the specificity was 0.95 (95%CI, 0.91–0.97). The LR+ and LR- were 7.90 (95% CI, 4.70–13.40), 0.61 (95% CI, 0.46–0.79), respectively. The AUC was 0.89 (95% CI, 0.86–0.92). Conclusion: The anti-M3R antibody had high specificity but relatively low sensitivity for the diagnosis of SS.

Suggested Citation

  • Chuiwen Deng & Chaojun Hu & Si Chen & Jing Li & Xiaoting Wen & Ziyan Wu & Yuan Li & Fengchun Zhang & Yongzhe Li, 2015. "Meta-Analysis of Anti-Muscarinic Receptor Type 3 Antibodies for the Diagnosis of Sjögren Syndrome," PLOS ONE, Public Library of Science, vol. 10(1), pages 1-9, January.
    • Handle: RePEc:plo:pone00:0116744
    DOI: 10.1371/journal.pone.0116744
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