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Age-Related Longitudinal Changes in Metabolic Energy Expenditure during Walking in Boys with Duchenne Muscular Dystrophy

Author

Listed:
  • Merel-Anne Brehm
  • Jiska C E Kempen
  • Anneke J van der Kooi
  • Imelda J M de Groot
  • Janneke C van den Bergen
  • Jan J G M Verschuuren
  • Erik H Niks
  • Jaap Harlaar

Abstract

Objective: The aim of this study was to evaluate age-related changes in metabolic walking energy expenditure in ambulant boys affected by Duchenne muscular dystrophy over a follow-up period of 12 months. Methods: At baseline (T1) and 12 months later (T2), metabolic walking energy expenditure was assessed during a 6-minute walk test at comfortable speed in 14 ambulant boys with Duchenne (age range: 6.0-12.5 years, mean 8.2). Outcome measures derived from the assessment included the 6-minute comfortable walking distance (m) and net-nondimensional energy cost relative to speed-matched control cost (SMC-EC, %). Statistical comparisons were made using a two-way repeated measures ANOVA (factors: time (T1 versus T2) and age ( 0.158), and also there were no interaction effects (p>0.248). Conclusions: The results of our small study suggest that the natural course of walking performance in ambulant boys with Duchenne is characterized by a decrease in comfortable walking distance and an increase in walking energy cost. The rate of energy cost seems to increase with age, while walking distance decreases, which is opposite from the trend in typically developing children.

Suggested Citation

  • Merel-Anne Brehm & Jiska C E Kempen & Anneke J van der Kooi & Imelda J M de Groot & Janneke C van den Bergen & Jan J G M Verschuuren & Erik H Niks & Jaap Harlaar, 2014. "Age-Related Longitudinal Changes in Metabolic Energy Expenditure during Walking in Boys with Duchenne Muscular Dystrophy," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0115200
    DOI: 10.1371/journal.pone.0115200
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