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Contraceptive Use and the Risk of Ectopic Pregnancy: A Multi-Center Case-Control Study

Author

Listed:
  • Cheng Li
  • Wei-Hong Zhao
  • Chun-Xia Meng
  • Hua Ping
  • Guo-Juan Qin
  • Shu-Jun Cao
  • Xiaowei Xi
  • Qian Zhu
  • Xiao-Cui Li
  • Jian Zhang

Abstract

Objective: To evaluate the association between the risk of ectopic pregnancy (EP) and the use of common contraceptives during the previous and current conception/menstrual cycle. Methods: A multi-center case-control study was conducted in Shanghai. Women diagnosed with EP were recruited as the case group (n = 2,411). Women with intrauterine pregnancy (IUP) (n = 2,416) and non-pregnant women (n = 2,419) were matched as controls at a ratio of 1∶1. Information regarding the previous and current use of contraceptives was collected. Multivariate logistic regression analyses were performed to calculate odds ratios (ORs) and the corresponding 95% confidential intervals (CIs). Results: Previous use of intrauterine devices (IUDs) was associated with a slight risk of ectopic pregnancy (AOR1 = 1.87 [95% CI: 1.48–2.37]; AOR2 = 1.84 [1.49–2.27]), and the risk increased with the duration of previous use (P1 for trend

Suggested Citation

  • Cheng Li & Wei-Hong Zhao & Chun-Xia Meng & Hua Ping & Guo-Juan Qin & Shu-Jun Cao & Xiaowei Xi & Qian Zhu & Xiao-Cui Li & Jian Zhang, 2014. "Contraceptive Use and the Risk of Ectopic Pregnancy: A Multi-Center Case-Control Study," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-17, December.
  • Handle: RePEc:plo:pone00:0115031
    DOI: 10.1371/journal.pone.0115031
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