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Clinicopathological and Prognostic Significance of CD24 Overexpression in Patients with Gastric Cancer: A Meta-Analysis

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  • Jing-Xun Wu
  • Yuan-Yuan Zhao
  • Xuan Wu
  • Han-Xiang An

Abstract

Objective: The prognostic significance of CD24 expression for survival in patients with gastric cancer remains controversial. We conducted a meta-analysis to investigate the impact of CD24 expression on clinicopathological features and survival outcomes in gastric cancer. Methods: A comprehensive literature search of the electronic databases PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI; up to April 8, 2014) was performed for relevant studies using multiple search strategies. Correlations between CD24 expression and clinicopathological features and overall survival (OS) were analyzed. Results: A total of 1,041 patients with gastric cancer from 9 studies were included. The pooled odds ratios (ORs) indicated CD24 expression was associated with tumor depth (OR = 0.45, 95% confidence interval [CI] = 0.32–0.63; P

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  • Jing-Xun Wu & Yuan-Yuan Zhao & Xuan Wu & Han-Xiang An, 2014. "Clinicopathological and Prognostic Significance of CD24 Overexpression in Patients with Gastric Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0114746
    DOI: 10.1371/journal.pone.0114746
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    Cited by:

    1. Guo-dong Cao & Ke Chen & Mao-ming Xiong & Bo Chen, 2016. "HER3, but Not HER4, Plays an Essential Role in the Clinicopathology and Prognosis of Gastric Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-14, August.

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