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Targeting Serum Glucocorticoid-Regulated Kinase-1 in Squamous Cell Carcinoma of the Head and Neck: A Novel Modality of Local Control

Author

Listed:
  • Henrik O Berdel
  • Hongyu Yin
  • Jun Yao Liu
  • Karolina Grochowska
  • Christopher Middleton
  • Nathan Yanasak
  • Rafik Abdelsayed
  • Wolfgang E Berdel
  • Mahmood Mozaffari
  • Jack C Yu
  • Babak Baban

Abstract

Purpose: The inhibition of serum glucocorticoid-regulated kinase-1 (SGK-1) has been found to decrease growth of colon and prostate cancer cells. The purpose of this study is to evaluate the therapeutic effect of SGK-1 inhibition in head and neck squamous cell carcinoma (SCC). Experimental Design: Human head and neck tumors (HTB41/43) were established in athymic mice. Growth rates between mice treated with vehicle (PBS) injection (group 1, n = 5), SGK-1 Inhibitor GSK 650394 (group 2, n = 6), systemic cisplatin (group 3, n = 6), and a combination of SGK-1 Inhibitor and cisplatin (group 4, n = 6) were compared using repeated measures one-way ANOVA with Newman-Keuls Multiple Comparison Test. Tumor cells were subsequently submitted to further analyses. Results: At the end of the experiment mean tumor sizes were 122.33+/−105.86, 76.73+/−36.09, 94.52+/−75.92, and 25.76+/−14.89 mm2 (mean +/− SD) for groups 1 to 4. Groups 2 and 3 showed decreased tumor growth compared to controls (p

Suggested Citation

  • Henrik O Berdel & Hongyu Yin & Jun Yao Liu & Karolina Grochowska & Christopher Middleton & Nathan Yanasak & Rafik Abdelsayed & Wolfgang E Berdel & Mahmood Mozaffari & Jack C Yu & Babak Baban, 2014. "Targeting Serum Glucocorticoid-Regulated Kinase-1 in Squamous Cell Carcinoma of the Head and Neck: A Novel Modality of Local Control," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-16, December.
    • Handle: RePEc:plo:pone00:0113795
    DOI: 10.1371/journal.pone.0113795
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