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Loss of 4q21.23-22.1 Is a Prognostic Marker for Disease Free and Overall Survival in Non-Small Cell Lung Cancer

Author

Listed:
  • Faik G Uzunoglu
  • Ebba Dethlefsen
  • Annkathrin Hanssen
  • Michaela Wrage
  • Lena Deutsch
  • Katharina Harms-Effenberger
  • Yogesh K Vashist
  • Matthias Reeh
  • Guido Sauter
  • Ronald Simon
  • Maximillian Bockhorn
  • Klaus Pantel
  • Jakob R Izbicki
  • Harriet Wikman

Abstract

This study was performed to assess the prognostic relevance of genomic aberrations at chromosome 4q in NSCLC patients. We have previously identified copy number changes at 4q12-q32 to be significantly associated with the early hematogenous dissemination of non-small cell lung cancer (NSCLC), and now aim to narrow down potential hot-spots within this 107 Mb spanning region. Using eight microsatellite markers at position 4q12-35, allelic imbalance (AI) analyses were performed on a preliminary study cohort (n = 86). Positions indicating clinicopathological and prognostic associations in AI analyses were further validated in a larger study cohort using fluorescence in situ hybridization (FISH) in 209 NSCLC patients. Losses at positions 4q21.23 and 4q22.1 were shown to be associated with advanced clinicopathological characteristics as well as with shortened disease free (DFS) and overall survival (OS) (DFS: P = 0.019; OS: P = 0.002). Multivariate analyses identified the losses of 4q21.23-22.1 to be an independent prognostic marker for both DFS and OS in NSCLC (HR 1.64–2.20, all P

Suggested Citation

  • Faik G Uzunoglu & Ebba Dethlefsen & Annkathrin Hanssen & Michaela Wrage & Lena Deutsch & Katharina Harms-Effenberger & Yogesh K Vashist & Matthias Reeh & Guido Sauter & Ronald Simon & Maximillian Bock, 2014. "Loss of 4q21.23-22.1 Is a Prognostic Marker for Disease Free and Overall Survival in Non-Small Cell Lung Cancer," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-17, December.
    • Handle: RePEc:plo:pone00:0113315
    DOI: 10.1371/journal.pone.0113315
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