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Low Serum 25-Hydroxyvitamin D Concentrations Are Associated with Increased Risk for Melanoma and Unfavourable Prognosis

Author

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  • Benjamin Bade
  • Alexander Zdebik
  • Stefan Wagenpfeil
  • Stefan Gräber
  • Jürgen Geisel
  • Thomas Vogt
  • Jörg Reichrath

Abstract

Background: Low vitamin D status (serum 25(OH)D concentration) is associated with increased incidence and unfavourable outcome of various types of cancer. However, there are limited data on influence of serum 25(OH)D on risk and prognosis of malignant melanoma. Methods: Basal serum 25(OH)D concentrations were retrospectively analyzed in a cohort of melanoma patients (n = 324) and healthy controls (n = 141). We tested the hypothesis that serum 25(OH)D concentrations are predictive of melanoma risk, thickness of primary melanomas, and overall survival (OS). Results: Median serum 25(OH)D concentrations were significantly lower (p = 0.004) in melanoma patients (median = 13.6 ng/ml) as compared to controls (median = 15.6 ng/ml). Primary tumors of patients with low serum 25(OH)D concentrations ( 20 ng/ml; median: 1.00 mm). Patients with 25(OH)D serum concentrations in the lowest quartile had inferior overall survival (median: 80 months) comparing with the highest quartile (median: 195 months; p = 0.049). Conclusions: Our data support the concept that serum 25(OH)D concentrations are associated with risk and prognosis of melanoma. Whether normalizing serum 25(OH)D concentrations in these patients improves outcomes will require testing in future clinical trials.

Suggested Citation

  • Benjamin Bade & Alexander Zdebik & Stefan Wagenpfeil & Stefan Gräber & Jürgen Geisel & Thomas Vogt & Jörg Reichrath, 2014. "Low Serum 25-Hydroxyvitamin D Concentrations Are Associated with Increased Risk for Melanoma and Unfavourable Prognosis," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-14, December.
    • Handle: RePEc:plo:pone00:0112863
    DOI: 10.1371/journal.pone.0112863
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