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Age-Related Cataract, Cataract Surgery and Subsequent Mortality: A Systematic Review and Meta-Analysis

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  • E Song
  • Hongpeng Sun
  • Yong Xu
  • Yana Ma
  • Hong Zhu
  • Chen-Wei Pan

Abstract

Purpose: Changes in lens may reflect the status of systemic health of human beings but the supporting evidences are not well summarized yet. We aimed to determine the relationship of age-related cataract, cataract surgery and long-term mortality by pooling the results of published population-based studies. Methods: We searched PubMed and Embase from their inception till March, 2014 for population-based studies reporting the associations of any subtypes of age-related cataract, cataract surgery with all-cause mortality. We pooled the effect estimates (hazards ratios [HRs]) under a random effects model. Results: Totally, we identified 10 unique population-based studies including 39,659 individuals at baseline reporting the associations of any subtypes of cataract with all-cause mortality from 6 countries. The presence of any cataract including cataract surgery was significantly associated with a higher risk of death (pooled HR: 1.43, 95% CI, 1.21, 2.02; P

Suggested Citation

  • E Song & Hongpeng Sun & Yong Xu & Yana Ma & Hong Zhu & Chen-Wei Pan, 2014. "Age-Related Cataract, Cataract Surgery and Subsequent Mortality: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-10, November.
    • Handle: RePEc:plo:pone00:0112054
    DOI: 10.1371/journal.pone.0112054
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