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Hyperhomocysteinemia in Patients with Polypoidal Choroidal Vasculopathy: A Case Control Study

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  • Hui-Chen Cheng
  • Jorn-Hon Liu
  • Shui-Mei Lee
  • Po-Kang Lin

Abstract

Purpose: To determine whether elevated plasma homocysteine and serum high sensitivity C-reactive protein (hsCRP) levels, two established risk factors of vascular diseases, are associated with polypoidal choroidal vasculopathy (PCV). Design: Retrospective case-control study. Methods: One hundred and nineteen consecutive patients with PCV and 119 matched controls were enrolled in a tertiary hospital from September 2008 to June 2013. Plasma homocysteine and serum hsCRP levels were measured. Associations among plasma homocysteine, serum hsCRP levels and PCV were further evaluated using multivariable logistic regression analysis. Results: The median plasma homocysteine level was significantly higher in patients with PCV than in the controls (12.20 µmol/L vs. 9.80 µmol/L, p

Suggested Citation

  • Hui-Chen Cheng & Jorn-Hon Liu & Shui-Mei Lee & Po-Kang Lin, 2014. "Hyperhomocysteinemia in Patients with Polypoidal Choroidal Vasculopathy: A Case Control Study," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-6, October.
    • Handle: RePEc:plo:pone00:0110818
    DOI: 10.1371/journal.pone.0110818
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