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Vitreous and Plasma VEGF Levels as Predictive Factors in the Progression of Proliferative Diabetic Retinopathy after Vitrectomy

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  • Jiaxing Wang
  • Song Chen
  • Feng Jiang
  • Caiyun You
  • Chunjie Mao
  • Jinguo Yu
  • Jindong Han
  • Zhuhong Zhang
  • Hua Yan

Abstract

Purpose: To investigate the vitreous and plasma levels of vascular endothelial growth factor (VEGF) in patients with proliferative diabetic retinopathy (PDR) and to determine whether they predict a disease prognosis after primary vitrectomy. Methods: Fifty patients (50 eyes) with PDR who underwent pars plana vitrectomy (PPV) and 56 healthy controls (56 eyes) were enrolled in this retrospective study. Clinical data were collected and analyzed. Vitreous and plasma VEGF concentrations were measured using enzyme-linked immunosorbent assays. VEGF levels and clinical data were compared and analyzed to see if they provide a prognosis of PDR progression after primary vitrectomy at more than 6 months follow-up. Correlation of VEGF concentrations between vitreous fluid and plasma was analyzed. Results: The average BCVA was significantly improved after surgery (P

Suggested Citation

  • Jiaxing Wang & Song Chen & Feng Jiang & Caiyun You & Chunjie Mao & Jinguo Yu & Jindong Han & Zhuhong Zhang & Hua Yan, 2014. "Vitreous and Plasma VEGF Levels as Predictive Factors in the Progression of Proliferative Diabetic Retinopathy after Vitrectomy," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-8, October.
    • Handle: RePEc:plo:pone00:0110531
    DOI: 10.1371/journal.pone.0110531
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