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Overexpression of Wip1 Is Associated with Biologic Behavior in Human Clear Cell Renal Cell Carcinoma

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  • Sulai Liu
  • Lin Qi
  • Weqing Han
  • Xinxing Wan
  • Shusuan Jiang
  • Yuan Li
  • Yu Xie
  • Longfei Liu
  • Fuhua Zeng
  • Zhizhong Liu
  • Xiongbing Zu

Abstract

Wild-type p53-induced phosphatase (Wip1 or PPM1D) has been reported to be aberrantly expressed in various cancers and correlated with the malignant behavior of cancer cells. However, the function of Wip1 in RCC remains unclear. The present study investigated its abnormal expression and dysfunctions in clear cell renal cell carcinoma (ccRCC) in vitro. With the combination of immunohistochemistry, western blotting, immunofluorescence, qRT-PCR, and cell proliferation, migration and invasion assays, we found that levels of Wip1 mRNA and protein were dramatically increased in human ccRCC tissues (P

Suggested Citation

  • Sulai Liu & Lin Qi & Weqing Han & Xinxing Wan & Shusuan Jiang & Yuan Li & Yu Xie & Longfei Liu & Fuhua Zeng & Zhizhong Liu & Xiongbing Zu, 2014. "Overexpression of Wip1 Is Associated with Biologic Behavior in Human Clear Cell Renal Cell Carcinoma," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-10, October.
    • Handle: RePEc:plo:pone00:0110218
    DOI: 10.1371/journal.pone.0110218
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