Author
Listed:
- Jen-Chih Tsai
- Yu-Huei Lin
- Po-Liang Lu
- Ni-Jiin Shen
- Chia-Jui Yang
- Nan-Yao Lee
- Hung-Jen Tang
- Yuag-Meng Liu
- Wen-Chi Huang
- Chen-Hsiang Lee
- Wen-Chien Ko
- Yen-Hsu Chen
- Hsi-Hsun Lin
- Tun-Chieh Chen
- Chien-Ching Hung
Abstract
Background: While doxycycline is recommended as an alternative treatment of syphilis in patients with penicillin allergy or intolerance, clinical studies to compare serological response to doxycycline versus benzathine penicillin in treatment of early syphilis among HIV-infected patients remain sparse. Methods: We retrospectively reviewed the medical records of HIV-infected patients with early syphilis who received doxycycline 100 mg twice daily for 14 days (doxycycline group) and those who received 1 dose of benzathine penicillin (2.4 million units) (penicillin group) between 2007 and 2013. Serological responses defined as a decline of rapid plasma reagin titer by 4-fold or greater at 6 and 12 months of treatment were compared between the two groups. Results: During the study period, 123 and 271 patients in the doxycycline and penicillin group, respectively, completed 6 months or longer follow-up. Ninety-one and 271 patients in the doxycycline and penicillin group, respectively, completed 12 months or longer follow-up. Clinical characteristics were similar between the two groups, except that, compared with penicillin group, doxycycline group had a lower proportion of patients with secondary syphilis (65.4% versus 41.5%, P
Suggested Citation
Jen-Chih Tsai & Yu-Huei Lin & Po-Liang Lu & Ni-Jiin Shen & Chia-Jui Yang & Nan-Yao Lee & Hung-Jen Tang & Yuag-Meng Liu & Wen-Chi Huang & Chen-Hsiang Lee & Wen-Chien Ko & Yen-Hsu Chen & Hsi-Hsun Lin & , 2014.
"Comparison of Serological Response to Doxycycline versus Benzathine Penicillin G in the Treatment of Early Syphilis in HIV-Infected Patients: A Multi-Center Observational Study,"
PLOS ONE, Public Library of Science, vol. 9(10), pages 1-7, October.
Handle:
RePEc:plo:pone00:0109813
DOI: 10.1371/journal.pone.0109813
Download full text from publisher
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0109813. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.