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Association of Common Variants in TCF4 and PTPRG with Fuchs' Corneal Dystrophy: A Systematic Review and Meta-Analysis

Author

Listed:
  • Lawrence C M Lau
  • Li Ma
  • Alvin L Young
  • Shi Song Rong
  • Vishal Jhanji
  • Marten E Brelen
  • Chi Pui Pang
  • Li Jia Chen

Abstract

Topic: A meta-analysis of TCF4 and PTPRG gene variants in Fuchs' corneal dystrophy (FCD). Clinical relevance: To identify novel genetic markers in patients with FCD in different ethnic populations. Methods: MEDLINE and EMBASE were searched for eligible genetic studies on TCF4 and PTPRG in FCD. Odds ratios (OR) and 95% confidence intervals (CI) of each single-nucleotide polymorphism (SNP) in allelic, dominant and recessive models were estimated using fixed-effect model if I2

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  • Lawrence C M Lau & Li Ma & Alvin L Young & Shi Song Rong & Vishal Jhanji & Marten E Brelen & Chi Pui Pang & Li Jia Chen, 2014. "Association of Common Variants in TCF4 and PTPRG with Fuchs' Corneal Dystrophy: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-8, October.
    • Handle: RePEc:plo:pone00:0109142
    DOI: 10.1371/journal.pone.0109142
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