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Prognostic Value of Polycomb Proteins EZH2, BMI1 and SUZ12 and Histone Modification H3K27me3 in Colorectal Cancer

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  • Anne Benard
  • Inès J Goossens-Beumer
  • Anneke Q van Hoesel
  • Hamed Horati
  • Hein Putter
  • Eliane C M Zeestraten
  • Cornelis J H van de Velde
  • Peter J K Kuppen

Abstract

Numerous changes in epigenetic mechanisms have been described in various types of tumors. In search for new biomarkers, we investigated the expression of Polycomb-group (PcG) proteins EZH2, BMI1 and SUZ12 and associated histone modification H3K27me3 in colorectal cancer. Nuclear expression of PcG proteins and histone modification H3K27me3 were immunohistochemically (IHC) stained on a tissue microarray (TMA), including 247 tumor tissues and 47 normal tissues, and scored using the semi-automated Ariol system. Tumor tissues showed higher expression of EZH2 (p = 0.05) and H3K27me3 (p

Suggested Citation

  • Anne Benard & Inès J Goossens-Beumer & Anneke Q van Hoesel & Hamed Horati & Hein Putter & Eliane C M Zeestraten & Cornelis J H van de Velde & Peter J K Kuppen, 2014. "Prognostic Value of Polycomb Proteins EZH2, BMI1 and SUZ12 and Histone Modification H3K27me3 in Colorectal Cancer," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-11, September.
    • Handle: RePEc:plo:pone00:0108265
    DOI: 10.1371/journal.pone.0108265
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