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Genetic Prediction of Antidepressant Drug Response and Nonresponse in Korean Patients

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  • Shinn-Won Lim
  • Hong-Hee Won
  • Hyeran Kim
  • Woojae Myung
  • Seonwoo Kim
  • Ka-Kyung Kim
  • Bernard J Carroll
  • Jong-Won Kim
  • Doh Kwan Kim

Abstract

Genetic polymorphism contributes to variation in response to drug treatment of depression. We conducted three independent 6-week treatment studies in outpatients with major depressive disorder (MDD) to develop a pharmacogenomic model predicting response and nonresponse. We screened candidate genomic markers for association with response to selective serotonin reuptake inhibitors (SSRIs). No patients had received any antidepressant drug treatment in the current episode of depression. Outcome evaluation was blinded to drug and genotype data. The prediction model derived from a development sample of 239 completer cases treated with SSRIs comprised haplotypes and polymorphisms related to serotonin synthesis, serotonin transport, glutamate receptors, and GABA synthesis. The model was evaluated prospectively for prediction of outcome in a validation sample of 176 new SSRI-treated completer cases. The model gave a prediction in 60% of these cases. Predictive values were 85% for predicted responders and 86% for predicted nonresponders, compared to prior probabilities of 66% for observed response and 34% for observed nonresponse in those cases (both P

Suggested Citation

  • Shinn-Won Lim & Hong-Hee Won & Hyeran Kim & Woojae Myung & Seonwoo Kim & Ka-Kyung Kim & Bernard J Carroll & Jong-Won Kim & Doh Kwan Kim, 2014. "Genetic Prediction of Antidepressant Drug Response and Nonresponse in Korean Patients," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-14, September.
    • Handle: RePEc:plo:pone00:0107098
    DOI: 10.1371/journal.pone.0107098
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    References listed on IDEAS

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    1. Katherine E Tansey & Michel Guipponi & Nader Perroud & Guido Bondolfi & Enrico Domenici & David Evans & Stephanie K Hall & Joanna Hauser & Neven Henigsberg & Xiaolan Hu & Borut Jerman & Wolfgang Maier, 2012. "Genetic Predictors of Response to Serotonergic and Noradrenergic Antidepressants in Major Depressive Disorder: A Genome-Wide Analysis of Individual-Level Data and a Meta-Analysis," PLOS Medicine, Public Library of Science, vol. 9(10), pages 1-10, October.
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