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Association between Tissue Characteristics of Coronary Plaque and Distal Embolization after Coronary Intervention in Acute Coronary Syndrome Patients: Insights from a Meta-Analysis of Virtual Histology-Intravascular Ultrasound Studies

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Listed:
  • Song Ding
  • Longwei Xu
  • Fan Yang
  • Lingcong Kong
  • Yichao Zhao
  • Lingchen Gao
  • Wei Wang
  • Rende Xu
  • Heng Ge
  • Meng Jiang
  • Jun Pu
  • Ben He

Abstract

Background and Objectives: The predictive value of plaque characteristics assessed by virtual histology-intravascular ultrasound (VH-IVUS) including fibrous tissue (FT), fibrofatty (FF), necrotic core (NC) and dense calcium (DC) in identifying distal embolization after percutaneous coronary intervention (PCI) is still controversial. We performed a systematic review and meta-analysis to summarize the association of pre-PCI plaque composition and post-PCI distal embolization in acute coronary syndrome patients. Methods: Studies were identified in PubMed, OVID, EMBASE, the Cochrane Library, the Current Controlled Trials Register, reviews, and reference lists of relevant articles. A meta-analysis using both fixed and random effects models with assessment of study heterogeneity and publication bias was performed. Results: Of the 388 articles screened, 10 studies with a total of 872 subjects (199 with distal embolization and 673 with normal flow) met the eligibility of our study. Compared with normal flow groups, significant higher absolute volume of NC [weighted mean differences (WMD): 5.79 mm3, 95% CI: 3.02 to 8.55 mm3; p

Suggested Citation

  • Song Ding & Longwei Xu & Fan Yang & Lingcong Kong & Yichao Zhao & Lingchen Gao & Wei Wang & Rende Xu & Heng Ge & Meng Jiang & Jun Pu & Ben He, 2014. "Association between Tissue Characteristics of Coronary Plaque and Distal Embolization after Coronary Intervention in Acute Coronary Syndrome Patients: Insights from a Meta-Analysis of Virtual Histolog," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-11, November.
    • Handle: RePEc:plo:pone00:0106583
    DOI: 10.1371/journal.pone.0106583
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