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Urinary Nerve Growth Factor Could Be a Biomarker for Interstitial Cystitis/Painful Bladder Syndrome: A Meta-Analysis

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  • Hong-Chen Qu
  • Wei Zhang
  • Shi Yan
  • Yi-Li Liu
  • Ping Wang

Abstract

To examine whether urinary nerve growth factor (NGF) could serve as a biomarker for interstitial cystitis/painful bladder syndrome (IC/PBS), we conducted a comprehensive meta-analysis of 9 studies. Among the studies considered, patients with IC/PBS had higher urinary NGF and NGF/Cr levels compared to those of healthy people (SMD = 1.94, 95%CI = 0.79–3.08, P = 0.0009 and SMD = 1.79, 95%CI = 0.65–2.93, P = 0.002, respectively). In addition, there was a significant difference between patients with IC/PBS and patients with overactive bladder (OAB) symptoms with respect to the urinary NGF and NGF/Cr levels (SMD = −0.62, 95%CI = −1.00–−0.24, P = 0.001 and SMD = −0.70, 95%CI = −1.01–−0.39, P

Suggested Citation

  • Hong-Chen Qu & Wei Zhang & Shi Yan & Yi-Li Liu & Ping Wang, 2014. "Urinary Nerve Growth Factor Could Be a Biomarker for Interstitial Cystitis/Painful Bladder Syndrome: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-8, September.
    • Handle: RePEc:plo:pone00:0106321
    DOI: 10.1371/journal.pone.0106321
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