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The Synergistic Effect of Functional Status and Comorbidity Burden on Mortality: A 16-Year Survival Analysis

Author

Listed:
  • Cynthia Chen
  • Isaac Sia
  • Hon-ming Ma
  • Bee Choo Tai
  • Angela Cheong
  • Ngan Phoon Fong
  • Shi Yu Julia Tan
  • Kin Ming Chan
  • Boon Yeow Tan
  • Edward Menon
  • Chye Hua Ee
  • Kok Keng Lee
  • Yee Sien Ng
  • Yik Ying Teo
  • Stefan Ma
  • Derrick Heng
  • Gerald Choon-Huat Koh

Abstract

Objectives: The relationship between disability and comorbidity on mortality is widely perceived as additive in clinical models of frailty. Design: National data were retrospectively extracted from medical records of community hospital. Data Sources: There were of 12,804 acutely-disabled patients admitted for inpatient rehabilitation in Singapore rehabilitation community hospitals from 1996 through 2005 were followed up for death till 31 December 2011. Outcome Measure: Cox proportional-hazards regression to assess the interaction of comorbidity and disability at discharge on all-cause mortality. Results: During a median follow-up of 10.9 years, there were 8,565 deaths (66.9%). The mean age was 73.0 (standard deviation: 11.5) years. Independent risk factors of mortality were higher comorbidity (p

Suggested Citation

  • Cynthia Chen & Isaac Sia & Hon-ming Ma & Bee Choo Tai & Angela Cheong & Ngan Phoon Fong & Shi Yu Julia Tan & Kin Ming Chan & Boon Yeow Tan & Edward Menon & Chye Hua Ee & Kok Keng Lee & Yee Sien Ng & Y, 2014. "The Synergistic Effect of Functional Status and Comorbidity Burden on Mortality: A 16-Year Survival Analysis," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-9, August.
    • Handle: RePEc:plo:pone00:0106248
    DOI: 10.1371/journal.pone.0106248
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