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The RADAR Study: Week 48 Safety and Efficacy of RAltegravir Combined with Boosted DARunavir Compared to Tenofovir/Emtricitabine Combined with Boosted Darunavir in Antiretroviral-Naive Patients. Impact on Bone Health

Author

Listed:
  • Roger J Bedimo
  • Henning Drechsler
  • Mamta Jain
  • James Cutrell
  • Song Zhang
  • Xilong Li
  • Irfan Farukhi
  • Rosinda Castanon
  • Pablo Tebas
  • Naim M Maalouf

Abstract

Background: NRTI-sparing regimens may avoid long-term mitochondrial, bone and renal toxicities and maintain viral suppression. Methods: In the RADAR study, 85 antiretroviral-naïve HIV-infected patients were randomized to receive either raltegravir (RAL) (n = 42) or tenofovir/emtricitabine (TDF/FTC) (n = 43), each with ritonavir-boosted darunavir (DRV/r). Virologic efficacy was assessed at weeks 24 and 48. Bone mineral density (BMD) was assessed by dual energy X-ray absorptiometry (DXA) scan at baseline and week 48, and bone turnover markers (BTM) assessed at weeks 0, 16 and 48. Results: Using an intention-to-treat analysis, 62.5% of RAL subjects and 83.7% of TDF/FTC subjects were responders (VL

Suggested Citation

  • Roger J Bedimo & Henning Drechsler & Mamta Jain & James Cutrell & Song Zhang & Xilong Li & Irfan Farukhi & Rosinda Castanon & Pablo Tebas & Naim M Maalouf, 2014. "The RADAR Study: Week 48 Safety and Efficacy of RAltegravir Combined with Boosted DARunavir Compared to Tenofovir/Emtricitabine Combined with Boosted Darunavir in Antiretroviral-Naive Patients. Impact," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-10, August.
    • Handle: RePEc:plo:pone00:0106221
    DOI: 10.1371/journal.pone.0106221
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