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A Predictive Model Combining Fecal Calgranulin B and Fecal Occult Blood Tests Can Improve the Diagnosis of Colorectal Cancer

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  • Byung Chang Kim
  • Jungnam Joo
  • Hee Jin Chang
  • Hyun Yang Yeo
  • Byong Chul Yoo
  • Boram Park
  • Ji Won Park
  • Dae Kyung Sohn
  • Chang Won Hong
  • Kyung Su Han

Abstract

Aim: Current fecal screening tools for colorectal cancer (CRC), such as fecal occult blood tests (FOBT), are limited by their low sensitivity. Calgranulin B (CALB) was previously reported as a candidate fecal marker for CRC. This study investigated whether a combination of the FOBT and fecal CALB has increased sensitivity and specificity for a diagnosis of CRC. Materials and Methods: Patients with CRC (n = 175), and healthy individuals (controls; n = 151) were enrolled into the development (81 cases and 51 controls) and validation (94 cases and 100 controls) sets. Stool samples were collected before bowel preparation. CALB levels were determined by western blotting. FOBT and fecal CALB results were used to develop a predictive model based on logistic regression analysis. The benefit of adding CALB to a model with only FOBT was evaluated as an increased area under the receiver operating curve (AUC), partial AUC, and reclassification improvement (RI) in cases and controls, and net reclassification improvement (NRI). Results: Mean CALB level was significantly higher in CRC patients than in controls (P

Suggested Citation

  • Byung Chang Kim & Jungnam Joo & Hee Jin Chang & Hyun Yang Yeo & Byong Chul Yoo & Boram Park & Ji Won Park & Dae Kyung Sohn & Chang Won Hong & Kyung Su Han, 2014. "A Predictive Model Combining Fecal Calgranulin B and Fecal Occult Blood Tests Can Improve the Diagnosis of Colorectal Cancer," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-7, September.
    • Handle: RePEc:plo:pone00:0106182
    DOI: 10.1371/journal.pone.0106182
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