IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0105844.html
   My bibliography  Save this article

Genome-Wide Association Study Identifies Variants in PMS1 Associated with Serum Ferritin in a Chinese Population

Author

Listed:
  • Ming Liao
  • Jianying Shi
  • Lirong Huang
  • Yong Gao
  • Aihua Tan
  • Chunlei Wu
  • Zheng Lu
  • Xiaobo Yang
  • Shijun Zhang
  • Yanlin Hu
  • Xue Qin
  • Jianling Li
  • Gang Chen
  • Jianfeng Xu
  • Zengnan Mo
  • Haiying Zhang

Abstract

Only a small proportion of genetic variation in serum ferritin has been explained by variant genetic studies, and genome-wide association study (GWAS) for serum ferritin has not been investigated widely in Chinese population. We aimed at exploring the novel genetic susceptibility to serum ferritin, and performed this two stage GWAS in a healthy Chinese population of 3,495 men aged 20–69 y, including 1,999 unrelated subjects in the first stage and 1,496 independent individuals in the second stage. Serum ferritin was measured with electrochemiluminescence immunoassay, and DNA samples were collected for genotyping. A total of 1,940,243 SNPs were tested by using multivariate linear regression analysis. After adjusting for population stratification, age and BMI, the rs5742933 located in the 5′UTR region of PMS1 gene on chromosome 2 was the most significantly associated with ferritin concentrations (P-combined = 2.329×10−10) (β = −0.11, 95% CI: −0.14, −0.07). Moreover, this marker was about 200kb away from the candidate gene SLC40A1 which is responsible for iron export. PMS1 gene was the novel genetic susceptibility to serum ferritin in Chinese males and its relation to SLC40A1 needs further study.

Suggested Citation

  • Ming Liao & Jianying Shi & Lirong Huang & Yong Gao & Aihua Tan & Chunlei Wu & Zheng Lu & Xiaobo Yang & Shijun Zhang & Yanlin Hu & Xue Qin & Jianling Li & Gang Chen & Jianfeng Xu & Zengnan Mo & Haiying, 2014. "Genome-Wide Association Study Identifies Variants in PMS1 Associated with Serum Ferritin in a Chinese Population," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-7, August.
    • Handle: RePEc:plo:pone00:0105844
    DOI: 10.1371/journal.pone.0105844
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105844
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0105844&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0105844?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Xiaobo Yang & Jielin Sun & Yong Gao & Aihua Tan & Haiying Zhang & Yanling Hu & Junjie Feng & Xue Qin & Sha Tao & Zhuo Chen & Seong-Tae Kim & Tao Peng & Ming Liao & Xiaoling Lin & Zengfeng Zhang & Minz, 2012. "Genome-Wide Association Study for Serum Complement C3 and C4 Levels in Healthy Chinese Subjects," PLOS Genetics, Public Library of Science, vol. 8(9), pages 1-8, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Abbas Khalili & Farhad Shokoohi & Masoud Asgharian & Shili Lin, 2023. "Sparse estimation in semiparametric finite mixture of varying coefficient regression models," Biometrics, The International Biometric Society, vol. 79(4), pages 3445-3457, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0105844. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.