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Adjuvant and Salvage Radiotherapy after Prostatectomy: A Systematic Review and Meta-Analysis

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  • Changhao Chen
  • Tianxin Lin
  • Yu Zhou
  • Doudou Li
  • Kewei Xu
  • Zhihua Li
  • Xinxiang Fan
  • Guangzheng Zhong
  • Wang He
  • Xu Chen
  • Xianyin He
  • Jian Huang

Abstract

Purpose: In men with adverse prognostic factors (APFs) after radical prostatectomy (RP), the most appropriate timing to administer radiotherapy remains a subject for debate. We conducted a systemic review and meta-analysis to evaluate the therapeutic strategies: adjuvant radiotherapy (ART) and salvage radiotherapy (SRT). Materials and Methods: We comprehensively searched PubMed, EMBASE, Web of Science and the Cochrane Library and performed the meta-analysis of all randomized controlled trials (RCTs) and retrospective comparative studies assessing the prognostic factors of ART and SRT. Results: Between May 1998 and July 2012, 2 matched control studies and 16 retrospective studies including a total of 2629 cases were identified (1404 cases for ART and 1185 cases for SRT). 5-year biochemical failure free survival (BFFS) for ART was longer than that for SRT (Hazard Ratio [HR]: 0.37; 95% CI, 0.30–0.46; p

Suggested Citation

  • Changhao Chen & Tianxin Lin & Yu Zhou & Doudou Li & Kewei Xu & Zhihua Li & Xinxiang Fan & Guangzheng Zhong & Wang He & Xu Chen & Xianyin He & Jian Huang, 2014. "Adjuvant and Salvage Radiotherapy after Prostatectomy: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-14, August.
    • Handle: RePEc:plo:pone00:0104918
    DOI: 10.1371/journal.pone.0104918
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