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ATO/ATRA/Anthracycline-Chemotherapy Sequential Consolidation Achieves Long-Term Efficacy in Primary Acute Promyelocytic Leukemia

Author

Listed:
  • Zi-Jie Long
  • Yuan Hu
  • Xu-Dong Li
  • Yi He
  • Ruo-Zhi Xiao
  • Zhi-Gang Fang
  • Dong-Ning Wang
  • Jia-Jun Liu
  • Jin-Song Yan
  • Ren-Wei Huang
  • Dong-Jun Lin
  • Quentin Liu

Abstract

The combination of all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3, ATO) has been effective in obtaining high clinical complete remission (CR) rates in acute promyelocytic leukemia (APL), but the long-term efficacy and safety among newly diagnosed APL patients are unclear. In this retrospective study, total 45 newly diagnosed APL patients received ATRA/chemotherapy combination regimen to induce remission. Among them, 43 patients (95.6%) achieved complete remission (CR) after induction therapy, followed by ATO/ATRA/anthracycline-based chemotherapy sequential consolidation treatment with a median follow-up of 55 months. In these patients, the estimated overall survival (OS) and the relapse-free survival (RFS) were 94.4%±3.9% and 94.6±3.7%, respectively. The toxicity profile was mild and reversible. No secondary carcinoma was observed. These results demonstrated the high efficacy and minimal toxicity of ATO/ATRA/anthracycline-based chemotherapy sequential consolidation treatment for newly diagnosed APL in long-term follow-up, suggesting a potential frontline therapy for APL.

Suggested Citation

  • Zi-Jie Long & Yuan Hu & Xu-Dong Li & Yi He & Ruo-Zhi Xiao & Zhi-Gang Fang & Dong-Ning Wang & Jia-Jun Liu & Jin-Song Yan & Ren-Wei Huang & Dong-Jun Lin & Quentin Liu, 2014. "ATO/ATRA/Anthracycline-Chemotherapy Sequential Consolidation Achieves Long-Term Efficacy in Primary Acute Promyelocytic Leukemia," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-8, August.
    • Handle: RePEc:plo:pone00:0104610
    DOI: 10.1371/journal.pone.0104610
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