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Pilot Quasi-Randomized Controlled Study of Herbal Medicine Hochuekkito as an Adjunct to Conventional Treatment for Progressed Pulmonary Mycobacterium avium Complex Disease

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  • Yasunori Enomoto
  • Eri Hagiwara
  • Shigeru Komatsu
  • Ryuichi Nishihira
  • Tomohisa Baba
  • Hideya Kitamura
  • Akimasa Sekine
  • Atsuhito Nakazawa
  • Takashi Ogura

Abstract

Introduction: Hochuekkito, a traditional herbal medicine, is occasionally prescribed in Japan to treat patients with a poor general condition. We aimed to examine whether this medicine was beneficial and tolerable for patients with progressed pulmonary Mycobacterium avium complex (MAC) disease. Methods: This pilot open-label quasi-randomized controlled trial enrolled 18 patients with progressed pulmonary MAC disease who had initiated antimycobacterial treatment over one year ago but were persistently culture-positive or intolerant. All patients continued their baseline treatment regimens with (n = 9) or without (n = 9) oral Hochuekkito for 24 weeks. Results: Baseline characteristics were generally similar between the groups. Most patients were elderly (median age 70 years), female, had a low body mass index (

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  • Yasunori Enomoto & Eri Hagiwara & Shigeru Komatsu & Ryuichi Nishihira & Tomohisa Baba & Hideya Kitamura & Akimasa Sekine & Atsuhito Nakazawa & Takashi Ogura, 2014. "Pilot Quasi-Randomized Controlled Study of Herbal Medicine Hochuekkito as an Adjunct to Conventional Treatment for Progressed Pulmonary Mycobacterium avium Complex Disease," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-8, August.
    • Handle: RePEc:plo:pone00:0104411
    DOI: 10.1371/journal.pone.0104411
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