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Statin Treatment in Hypercholesterolemic Men Does Not Attenuate Angiotensin II-Induced Venoconstriction

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  • Christoph Schindler
  • Kristina Guenther
  • Cosima Hermann
  • Carlos M Ferrario
  • Christoph Schroeder
  • Sven Haufe
  • Jens Jordan
  • Wilhelm Kirch

Abstract

: Experimental studies suggested that statins attenuate vascular AT1 receptor responsiveness. Moreover, the augmented excessive pressor response to systemic angiotensin II infusions in hypercholesterolemic patients was normalized with statin treatment. In 12 hypercholesterolemic patients, we tested the hypothesis that statin treatment attenuates angiotensin II-mediated vasoconstriction in hand veins assessed by a linear variable differential transducer. Subjects ingested daily doses of either atorvastatin (40 mg) or positive control irbesartan (150 mg) for 30 days in a randomized and cross-over fashion. Ang II–induced venoconstriction at minute 4 averaged 59%±10% before and 28%±9% after irbesartan (mean ± SEM; P

Suggested Citation

  • Christoph Schindler & Kristina Guenther & Cosima Hermann & Carlos M Ferrario & Christoph Schroeder & Sven Haufe & Jens Jordan & Wilhelm Kirch, 2014. "Statin Treatment in Hypercholesterolemic Men Does Not Attenuate Angiotensin II-Induced Venoconstriction," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-7, September.
    • Handle: RePEc:plo:pone00:0103909
    DOI: 10.1371/journal.pone.0103909
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