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Decreased Circulating Visfatin Is Associated with Improved Disease Activity in Early Rheumatoid Arthritis: Data from the PERAC Cohort

Author

Listed:
  • Ondřej Sglunda
  • Heřman Mann
  • Hana Hulejová
  • Markéta Kuklová
  • Ondřej Pecha
  • Lenka Pleštilová
  • Mária Filková
  • Karel Pavelka
  • Jiří Vencovský
  • Ladislav Šenolt

Abstract

Objective: To evaluate circulating visfatin and its relationship with disease activity and serum lipids in patients with early, treatment-naïve rheumatoid arthritis (RA). Methods: Serum visfatin was measured in 40 patients with early RA before and after three months of treatment and in 30 age- and sex-matched healthy individuals. Disease activity was assessed using the Disease Activity Score for 28 joints (DAS28) at baseline and at three and 12 months. Multivariate linear regression analysis was performed to evaluate whether improved disease activity is related to serum visfatin or a change in visfatin level. Results: Serum visfatin was significantly elevated in early RA patients compared to healthy controls (1.92±1.17 vs. 1.36±0.93 ng/ml; p = 0.034) and significantly decreased after three months of treatment (to 0.99±0.67 ng/ml; p

Suggested Citation

  • Ondřej Sglunda & Heřman Mann & Hana Hulejová & Markéta Kuklová & Ondřej Pecha & Lenka Pleštilová & Mária Filková & Karel Pavelka & Jiří Vencovský & Ladislav Šenolt, 2014. "Decreased Circulating Visfatin Is Associated with Improved Disease Activity in Early Rheumatoid Arthritis: Data from the PERAC Cohort," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-5, July.
    • Handle: RePEc:plo:pone00:0103495
    DOI: 10.1371/journal.pone.0103495
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