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BRAF Mutations in Patients with Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

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Listed:
  • Dong Chen
  • Li-Qun Zhang
  • Jun-Fu Huang
  • Kai Liu
  • Zheng-Ran Chuai
  • Zhao Yang
  • Yun-Xia Wang
  • Da-Chuan Shi
  • Qian Liu
  • Qing Huang
  • Wei-Ling Fu

Abstract

Background: BRAF mutations have been well described in non-small cell lung cancer (NSCLC) for several years, but the clinical features of patients harboring BRAF mutations are still not well described. We performed a meta-analysis to identify common clinical features in NSCLC patients carrying BRAF mutations. Methods: We identified clinical studies that examined the association between BRAF mutations and features of NSCLC within PubMed, Embase and ISI Science Citation Index database up to October 2013. The effect size of clinical features was estimated by odds ratios (ORs) with 95% confidence interval (CI) for each study, using a fixed-effects or random-effects model. Results: Ten studies with a total of 5599 NSCLC patients were included. There was a 3% (170/5599) BRAF mutation rate. BRAF mutations in NSCLC were significantly associated with adenocarcinomas (ADCs) (compared with non-ADCs, OR = 4.96, 95%CI = 2.29–10.75). There were no significant differences in gender, smoking and stage in patients with and without BRAF mutations. The BRAFV600E mutation was more frequent in women than non-BRAFV600E mutations (OR = 0.27, 95%CI = 0.12–0.59), and was closely related to never smokers (OR = 0.14, 95%CI = 0.05–0.42). Conclusions: These findings have important implications for the prediction of the NSCLC sub-types more accurately combined with other genetic changes.

Suggested Citation

  • Dong Chen & Li-Qun Zhang & Jun-Fu Huang & Kai Liu & Zheng-Ran Chuai & Zhao Yang & Yun-Xia Wang & Da-Chuan Shi & Qian Liu & Qing Huang & Wei-Ling Fu, 2014. "BRAF Mutations in Patients with Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0101354
    DOI: 10.1371/journal.pone.0101354
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    References listed on IDEAS

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    1. She-Juan An & Zhi-Hong Chen & Jian Su & Xu-Chao Zhang & Wen-Zhao Zhong & Jin-Ji Yang & Qing Zhou & Xue-Ning Yang & Ling Huang & Ji-Lin Guan & Qiang Nie & Hong-Hong Yan & Tony S Mok & Yi-Long Wu, 2012. "Identification of Enriched Driver Gene Alterations in Subgroups of Non-Small Cell Lung Cancer Patients Based on Histology and Smoking Status," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-8, June.
    2. Gholamreza Safaee Ardekani & Seyed Mehdi Jafarnejad & Larry Tan & Ardavan Saeedi & Gang Li, 2012. "The Prognostic Value of BRAF Mutation in Colorectal Cancer and Melanoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-10, October.
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