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Association between Thrombophilia Gene Polymorphisms and Preeclampsia: A Meta-Analysis

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  • Xi Wang
  • Tingting Bai
  • Shengnan Liu
  • Hong Pan
  • Binbin Wang

Abstract

Objective: To estimate the relationship between the risk of preeclampsia and two thrombophilia gene single-nucleotide polymorphisms (SNPs), the factor V G1691A SNP and the prothrombin G20210A SNP. Date Sources: A systematic search of the English-language literature up to November 2012 was performed using Medline and EMBASE. Search terms included “preeclampsia,” “thrombophilia,” “factor V Leiden,” “prothrombin gene 20210,” and their combinations. Result(s): Thirty-seven studies with 5048 preeclampsia patients and 6796 controls were included in the meta-analysis. We found that the prothrombin G20210A polymorphism was associated with an increased risk of all preeclampsia (pooled odds ratio (OR) = 1.81, 95% confidence interval (CI) 1.25–2.63) and severe preeclampsia (pooled OR = 3.02, 95%CI 2.06–4.45). Meanwhile, the pooled OR for the association between factor V Leiden and all preeclampsia was 1.60 (95%CI 1.28–2.00) and 2.45 (95%CI 1.63–3.69) for the cases of severe preeclampsia. Conclusion(s): This meta-analysis supports that the factor V G1691A SNP and the prothrombin G20210A SNP are associated with an increased risk for both preeclampsia overall and severe preeclampsia.

Suggested Citation

  • Xi Wang & Tingting Bai & Shengnan Liu & Hong Pan & Binbin Wang, 2014. "Association between Thrombophilia Gene Polymorphisms and Preeclampsia: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0100789
    DOI: 10.1371/journal.pone.0100789
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