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Admission Cell Free DNA Levels Predict 28-Day Mortality in Patients with Severe Sepsis in Intensive Care

Author

Listed:
  • Avital Avriel
  • Maya Paryente Wiessman
  • Yaniv Almog
  • Yael Perl
  • Victor Novack
  • Ori Galante
  • Moti Klein
  • Michael J Pencina
  • Amos Douvdevani

Abstract

Aim: The aim of the current study is to assess the mortality prediction accuracy of circulating cell-free DNA (CFD) level at admission measured by a new simplified method. Materials and Methods: CFD levels were measured by a direct fluorescence assay in severe sepsis patients on intensive care unit (ICU) admission. In-hospital and/or twenty eight day all-cause mortality was the primary outcome. Results: Out of 108 patients with median APACHE II of 20, 32.4% have died in hospital/or at 28-day. CFD levels were higher in decedents: median 3469.0 vs. 1659 ng/ml, p

Suggested Citation

  • Avital Avriel & Maya Paryente Wiessman & Yaniv Almog & Yael Perl & Victor Novack & Ori Galante & Moti Klein & Michael J Pencina & Amos Douvdevani, 2014. "Admission Cell Free DNA Levels Predict 28-Day Mortality in Patients with Severe Sepsis in Intensive Care," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0100514
    DOI: 10.1371/journal.pone.0100514
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    Cited by:

    1. Mohammad Najm Dadam & Le Thanh Hien & Engy M Makram & Lam Vinh Sieu & Ahmad Morad & Nada Khalil & Linh Tran & Abdelrahman M Makram & Nguyen Tien Huy, 2024. "Role of cell-free DNA levels in the diagnosis and prognosis of sepsis and bacteremia: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 19(8), pages 1-16, August.

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