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Effects of Tumor Necrosis Factor-β (TNF-β) 252A>G Polymorphism on the Development of Migraine: A Meta-Analysis

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Listed:
  • Ruozhuo Liu
  • Minghui Ma
  • Mingyu Cui
  • Zhao Dong
  • Xiaolin Wang
  • Wei Zhang
  • Minghui Yang
  • Shengyuan Yu

Abstract

Background and Objective: Genetic factors including TNF-β have been considered as important components in the aetiology of migraine. Many studies have investigated the association between TNF-β 252A>G polymorphism and migraine risk, with debatable results. This study was designed to examine whether the TNF-β 252A>G polymorphism confers genetic susceptibility to migraine in diverse populations. Method: Studies eligible for this meta-analysis were searched in the PubMed, Embase, and CNKI by using the keywords “tumor necrosis factor”, “TNF”, “252A>G”, “rs909253”, “polymorphism”, “polymorphisms”, “variant”, “SNP”, combined with “migraine” or “migraine with aura (MA)” or “migraine without aura (MO)”. Pooled ORs and 95% CI were appropriately calculated using the fixed-effect model. Results: We finally included a total of seven studies, providing 5 557 migraineurs and 20 543 unrelated healthy controls. Meta-analysis results showed no statistical evidence of a significant association between TNF-β 252A>G polymorphism and overall migraine risk. Stratified analyses by type of migraine and gender revealed similar results. Interestingly, an OR with 95% CI representing an increased migraine risk was indicated in Asians under the recessive model (GG vs. AG + AA: OR, 1.38; 95%CI, 1.04–1.84; P for heterogeneity, 0.665). Conclusions: Our findings appear to support the hypothesis that genetic variability of 252A>G polymorphism in TNF region may modulate risk of migraine in the population of Asian ancestry.

Suggested Citation

  • Ruozhuo Liu & Minghui Ma & Mingyu Cui & Zhao Dong & Xiaolin Wang & Wei Zhang & Minghui Yang & Shengyuan Yu, 2014. "Effects of Tumor Necrosis Factor-β (TNF-β) 252A>G Polymorphism on the Development of Migraine: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-6, June.
    • Handle: RePEc:plo:pone00:0100189
    DOI: 10.1371/journal.pone.0100189
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