IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0100003.html
   My bibliography  Save this article

Correlation Analysis of EV71 Detection and Case Severity in Hand, Foot, and Mouth Disease in the Hunan Province of China

Author

Listed:
  • Li-Dong Gao
  • Shi-Xiong Hu
  • Hong Zhang
  • Kai-Wei Luo
  • Yun-Zhi Liu
  • Qiao-Hua Xu
  • Wei Huang
  • Zhi-Hong Deng
  • Shuai-Feng Zhou
  • Fu-Qiang Liu
  • Fan Zhang
  • Yu Chen

Abstract

An increase in the incidence of hand, foot and mouth disease (HFMD) cases has been observed in the Hunan province of mainland China since 2009 with a particularly higher level of severe cases in 2010–2012. Intestinal viruses of the picornaviridae family are responsible for the human syndrome associated with HFMD with enterovirus 71 (EV71) and Coxsackievirus A16 (Cox A16) being the most common causative strains. HFMD cases associated with EV71 are generally more severe with an increased association of morbidity and mortality. In this study, the etiology surveillance data of HFMD cases in Hunan province from March 2010 to October 2012 were analyzed to determine if there is a statistically relevant linear correlation exists between the detection rate of EV71 in mild cases and the proportion of severe cases among all HFMD patients. As the cases progressed from mild to severe to fatal, the likelihood of EV71 detection increased (25.78%, 52.20% and 84.18%, respectively). For all cases in the timeframe evaluated in this study, the presence of virus was detected in 63.21% of cases; among cases showing positivity for virus, EV71 infection accounted for 50.14%. These results provide evidence to support the observed higher morbidity and mortality associated with this outbreak and emphasizes the importance of early detection in order to implement necessary prevention measures to mitigate disease progression.

Suggested Citation

  • Li-Dong Gao & Shi-Xiong Hu & Hong Zhang & Kai-Wei Luo & Yun-Zhi Liu & Qiao-Hua Xu & Wei Huang & Zhi-Hong Deng & Shuai-Feng Zhou & Fu-Qiang Liu & Fan Zhang & Yu Chen, 2014. "Correlation Analysis of EV71 Detection and Case Severity in Hand, Foot, and Mouth Disease in the Hunan Province of China," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-6, June.
  • Handle: RePEc:plo:pone00:0100003
    DOI: 10.1371/journal.pone.0100003
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100003
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100003&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0100003?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0100003. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.