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Association of Adrenal Function and Disease Severity in Community-Acquired Pneumonia

Author

Listed:
  • Cornelia Mueller
  • Claudine A Blum
  • Michael Trummler
  • Daiana Stolz
  • Roland Bingisser
  • Christian Mueller
  • Michael Tamm
  • Beat Mueller
  • Philipp Schuetz
  • Mirjam Christ-Crain

Abstract

Introduction: Rapid and accurate risk stratification in patients with community-acquired pneumonia (CAP) is an unmet clinical need. Cortisol to dehydroepiandrosterone (DHEA) ratio was put forward as a prognostic marker in sepsis. We herein validated the prognostic value of the adrenal hormones DHEA, DHEA-Sulfate (DHEAS), cortisol/DHEA-, cortisol/DHEAS- and DHEA/DHEAS – ratios in patients with CAP. Methods: We assessed severity of illness using the pneumonia severity index (PSI) and measured adrenal hormone concentrations in 179 serum samples of prospectively recruited patients hospitalized with CAP. We calculated spearman rank correlation, logistic regression analysis and Kaplan Meier curves to study associations of adrenal hormones and outcomes. Results: There was a significant correlation between PSI score and total cortisol (r = 0.24, p = 0.001), DHEAS (r = −0.23, p = 0.002), cortisol/DHEA (r = 0.23, p = 0.003), cortisol/DHEAS (r = 0.32, p =

Suggested Citation

  • Cornelia Mueller & Claudine A Blum & Michael Trummler & Daiana Stolz & Roland Bingisser & Christian Mueller & Michael Tamm & Beat Mueller & Philipp Schuetz & Mirjam Christ-Crain, 2014. "Association of Adrenal Function and Disease Severity in Community-Acquired Pneumonia," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-6, June.
    • Handle: RePEc:plo:pone00:0099518
    DOI: 10.1371/journal.pone.0099518
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