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A Meta-Analysis of Mortality in End-Stage Renal Disease Patients Receiving Implantable Cardioverter Defibrillators (ICDs)

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  • Tien-Hsing Chen
  • Hung-Ta Wo
  • Po-Cheng Chang
  • Chun-Chieh Wang
  • Ming-Shien Wen
  • Chung-Chuan Chou

Abstract

Data on the effectiveness of implantable implantable cardioverter defibrillators (ICDs) with respect to reducing mortality in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) are lacking. The purpose of this meta-analysis was to compare the mortality of patients with ESRD who have received and not received an ICD. A search was conducted on January 31, 2013 of Medline, Cochrane, EMBASE, and Google Scholar. Studies were selected for inclusion based on the following criteria. 1) Randomized controlled trial. 2) ESRD patients with heart failure. 3) Device therapy (ICD, CRT-defibrillator [CRT-D]) used to treat heart failure. 4) Primary outcome is survival analysis. 5) Retrospective study if survival analysis was performed. The primary outcome was overall survival (OS), and the secondary outcome was 2-year survival. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated, and a χ2-based test of homogeneity was performed. Three studies were included in the analysis. The combined OR for OS was 2.245 (95% CI 1.871 to 2.685, P

Suggested Citation

  • Tien-Hsing Chen & Hung-Ta Wo & Po-Cheng Chang & Chun-Chieh Wang & Ming-Shien Wen & Chung-Chuan Chou, 2014. "A Meta-Analysis of Mortality in End-Stage Renal Disease Patients Receiving Implantable Cardioverter Defibrillators (ICDs)," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-6, July.
    • Handle: RePEc:plo:pone00:0099418
    DOI: 10.1371/journal.pone.0099418
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