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Insulin-Like Growth Factor-1 as a Prognostic Marker in Patients with Acute Ischemic Stroke

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  • Jian-Hua Tang
  • Li-Li Ma
  • Tian-Xia Yu
  • Juan Zheng
  • Hui-Juan Zhang
  • Hui Liang
  • Peng Shao

Abstract

Objective: Insulin-like growth factor-1 (IGF-1) has been associated with cardiovascular risk factors and atherosclerosis. The aim of the present study was to evaluate the prognostic value of IGF-1 levels in patients with acute ischemic stroke (AIS). Methods: All patients with first-ever AIS from August 1, 2012 to August 31, 2013 were recruited to participate in the study. Clinical data were collected. The National Institutes of Health Stroke Scale (NIHSS) score was assessed on admission blinded to serum IGF-1 levels. For the assessment of functional outcome at 90 days Modified Rankin Scale (mRS) was used. On admission, serum IGF-1 levels were determined by chemiluminescence immunoassay. The influence of IGF-1 levels on functional outcome and death was assessed by multivariate logistic regression analysis. Results: Patients with an unfavorable outcomes and non-survivors had significantly decreased serum IGF-1 levels on admission (P

Suggested Citation

  • Jian-Hua Tang & Li-Li Ma & Tian-Xia Yu & Juan Zheng & Hui-Juan Zhang & Hui Liang & Peng Shao, 2014. "Insulin-Like Growth Factor-1 as a Prognostic Marker in Patients with Acute Ischemic Stroke," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0099186
    DOI: 10.1371/journal.pone.0099186
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