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The Impact of Drug Reimbursement Policy on Rates of Testosterone Replacement Therapy among Older Men

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  • Jolanta Piszczek
  • Muhammad Mamdani
  • Tony Antoniou
  • David N Juurlink
  • Tara Gomes

Abstract

Background: Despite a lack of data describing the long-term efficacy and safety of testosterone replacement therapy (TRT), prescribing of testosterone to older men has increased with the availability of topical formulations. The magnitude of this increase and the impact of formulary restrictions on testosterone prescribing are poorly characterized. Methods: We conducted a time series analysis using the linked health administrative records of men aged 66 years or older in Ontario, Canada between January 1, 1997 and March 31, 2012. We used interventional autoregressive integrated moving average models to examine the impact of a restrictive drug reimbursement policy on testosterone prescribing and examined the demographic profile of men initiating testosterone in the final 2 years of the study period. Results: A total of 28,477 men were dispensed testosterone over the study period. Overall testosterone prescribing declined 27.9% in the 6 months following the implementation of the restriction policy (9.5 to 6.9 men per 1000 eligible; p

Suggested Citation

  • Jolanta Piszczek & Muhammad Mamdani & Tony Antoniou & David N Juurlink & Tara Gomes, 2014. "The Impact of Drug Reimbursement Policy on Rates of Testosterone Replacement Therapy among Older Men," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-6, July.
    • Handle: RePEc:plo:pone00:0098003
    DOI: 10.1371/journal.pone.0098003
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