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Cardiac High-Energy Phosphate Metabolism Alters with Age as Studied in 196 Healthy Males with the Help of 31-Phosphorus 2-Dimensional Chemical Shift Imaging

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  • Regina Esterhammer
  • Gert Klug
  • Christian Wolf
  • Agnes Mayr
  • Sebastian Reinstadler
  • Hans-Josef Feistritzer
  • Bernhard Metzler
  • Michael F H Schocke

Abstract

Recently published studies have elucidated alterations of mitochondrial oxidative metabolism during ageing. The intention of the present study was to evaluate the impact of ageing on cardiac high-energy phosphate metabolism and cardiac function in healthy humans. 31-phosphorus 2-dimensional chemical shift imaging (31P 2D CSI) and echocardiography were performed in 196 healthy male volunteers divided into groups of 20 to 40 years (I, n = 43), 40 to 60 years (II, n = 123) and >60 years (III, n = 27) of age. Left ventricular PCr/β-ATP ratio, myocardial mass (MM), ejection fraction and E/A ratio were assessed. Mean PCr/β-ATP ratios were significantly different among the three groups of volunteers (I, 2.10±0.37; II, 1.77±0.37; III, 1.45±0.28; all p

Suggested Citation

  • Regina Esterhammer & Gert Klug & Christian Wolf & Agnes Mayr & Sebastian Reinstadler & Hans-Josef Feistritzer & Bernhard Metzler & Michael F H Schocke, 2014. "Cardiac High-Energy Phosphate Metabolism Alters with Age as Studied in 196 Healthy Males with the Help of 31-Phosphorus 2-Dimensional Chemical Shift Imaging," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-9, June.
    • Handle: RePEc:plo:pone00:0097368
    DOI: 10.1371/journal.pone.0097368
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