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The SNP rs1883832 in CD40 Gene and Risk of Atherosclerosis in Chinese Population: A Meta-Analysis

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  • Yan Yun
  • Chi Ma
  • XiaoChun Ma

Abstract

Background: The complications of atherosclerosis such as coronary and cerebrovascular disease, are the most prevalent causes of mortality and morbidity worldwide. A single nucleotide polymorphism (SNP) rs1883832 (-1C/T) in CD40 gene has been recently suggested to contribute to the susceptibility to atherosclerosis in Chinese population; however, previous genetic association studies yielded inconsistent results. Methods: A meta-analysis of eligible studies reporting the association between rs1883832 and atherosclerosis in Chinese population was carried out. Results: Pooling 7 eligible case-control studies involving 2129 patients and 1895 controls demonstrated a significant association between rs1883832 and atherosclerosis under dominant model [odds ratio (OR) = 1.631, 95% confidence interval [CI] [1.176, 2.260] in Chinese population with evident heterogeneity. Meta-regression analysis indicated that the heterogeneity could be completely explained by disease category. In subgroup analysis, rs1883832 conferred ORs of 2.866 (C/C versus T/T, 95%CI [2.203, 3.729]) and 1.680 (C/T versus T/T, 95%CI [1.352, 2.086]) for coronary artery disease (CAD) under co-dominant model without heterogeneity. Similar results were obtained for acute coronary syndrome (ACS) (C/C versus T/T, 3.674, 95%CI [2.638, 5.116]; C/T versus T/T, 1.981, 95%CI [1.483, 2.646]). The other genetic models including dominant, recessive and additive models, yielded consistent results without heterogeneity for CAD and ACS, respectively. However, a protective role was found for C allele in ischemic stroke (IS) under recessive model (0.582, 95%CI [0.393, 0.864]) and additive model (0.785, 95%CI [0.679, 0.909]) with reduced heterogeneity. Conclusions: This meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.

Suggested Citation

  • Yan Yun & Chi Ma & XiaoChun Ma, 2014. "The SNP rs1883832 in CD40 Gene and Risk of Atherosclerosis in Chinese Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0097289
    DOI: 10.1371/journal.pone.0097289
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    1. Xiawen Zheng & Li Wang & Yaowu Zhu & Qing Guan & Huijun Li & Zhigang Xiong & Lingyan Deng & Jie Lu & Xiaoping Miao & Liming Cheng, 2012. "The SNP rs961253 in 20p12.3 Is Associated with Colorectal Cancer Risk: A Case-Control Study and a Meta-Analysis of the Published Literature," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-7, April.
    2. Xu Liu & Ruixia Zhu & Lei Li & Shumin Deng & Qu Li & Zhiyi He, 2013. "Genetic Polymorphism in PDE4D Gene and Risk of Ischemic Stroke in Chinese Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
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