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Effect of Amifostine in Head and Neck Cancer Patients Treated with Radiotherapy: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials

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  • Jundong Gu
  • Siwei Zhu
  • Xuebing Li
  • Hua Wu
  • Yang Li
  • Feng Hua

Abstract

Background: Amifostine is the most clinical used chemical radioprotector, but its effect in patients treated with radiation is not consistent. Methods: By searching Medline, CENTRAL, EMBASE, ASCO, ESMO, and CNKI databases, the published randomized controlled trials (RCTs) about the efficacy of amifostine in HNSCC patients treated with radiotherapy were collected. The pooled efficacy and side effects of this drug were calculated by RevMan software. Results: Seventeen trials including a total of 1167 patients (604 and 563 each arm) were analyzed in the meta-analysis. The pooled data showed that the use of amifostine significantly reduce the risk of developing Grade3–4 mucositis (relative risk [RR],0.72; 95% confidence interval [CI],0.54–0.95; p

Suggested Citation

  • Jundong Gu & Siwei Zhu & Xuebing Li & Hua Wu & Yang Li & Feng Hua, 2014. "Effect of Amifostine in Head and Neck Cancer Patients Treated with Radiotherapy: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-9, May.
    • Handle: RePEc:plo:pone00:0095968
    DOI: 10.1371/journal.pone.0095968
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