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Diabetes Mellitus and Poorer Prognosis in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

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  • Yan-Gang Wang
  • Peng Wang
  • Bin Wang
  • Zheng-Ju Fu
  • Wen-Juan Zhao
  • Sheng-Li Yan

Abstract

Background: Previous studies suggested that diabetes mellitus was associated with cancer risk and prognosis, but studies investigating the relationship between diabetes mellitus and survival in patients with hepatocellular carcinoma (HCC) reported inconsistent findings. To derive a more precise estimate of the prognostic role of diabetes mellitus in HCC, we systematically reviewed published studies and carried out a meta-analysis. Methods: Eligible articles were identified in electronic databases from their inception through September 16, 2013. To evaluate the correlation between diabetes mellitus and prognosis in HCC, the pooled hazard ratios (HR) and their 95% confidence intervals (95% CI) for poorer overall and disease-free survivals were calculated by standard meta-analysis techniques with fixed-effects or random-effects models. Results: 21 studies with a total of 9,767 HCC patients stratifying overall survival and/or disease-free survival in HCC patients by diabetes mellitus status were eligible for meta-analysis. 20 studies with a total of 9,727 HCC cases investigated the overall survival, and 10 studies with a total of 2,412 HCC patients investigated the disease-free survival. The pooled HRs for overall survival and disease-free survival were 1.46 (95% CI, 1.29 to 1.66; P

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  • Yan-Gang Wang & Peng Wang & Bin Wang & Zheng-Ju Fu & Wen-Juan Zhao & Sheng-Li Yan, 2014. "Diabetes Mellitus and Poorer Prognosis in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-7, May.
    • Handle: RePEc:plo:pone00:0095485
    DOI: 10.1371/journal.pone.0095485
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    Cited by:

    1. Yu-Wen Su & Po-Hong Liu & Chia-Yang Hsu & Yun-Hsuan Lee & Cheng-Yuan Hsia & Shu-Yein Ho & Ming-Chih Hou & Harn-Shen Chen & Teh-Ia Huo, 2017. "Prognostic impact of diabetes mellitus on hepatocellular carcinoma: Special emphasis from the BCLC perspective," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-12, March.

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