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The Effect of Laterality and Primary Tumor Site on Cancer-Specific Mortality in Breast Cancer: A SEER Population-Based Study

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  • Jing Bao
  • Ke-Da Yu
  • Yi-Zhou Jiang
  • Zhi-Ming Shao
  • Gen-Hong Di

Abstract

Background: Reduced overall survival has been observed in patients with left-sided versus right-sided breast cancer due to cardiac toxicity after radiotherapy. However, the effect of laterality and primary tumor site on breast cancer-specific mortality (BCSM) remains unclear. Patients and Methods: We analyzed data from 305,443 women ages 20- to 79-years-old diagnosed with breast cancer between 1990 and 2009. The data were obtained from the population-based Surveillance, Epidemiology, and End Results (SEER) program of the U.S. National Cancer Institute. The survival outcomes with regard to laterality and primary tumor site were compared using univariate and multivariate (Cox proportional hazards regression model) methods. Results: In the multivariate analysis, BCSM was affected by the primary tumor site (P

Suggested Citation

  • Jing Bao & Ke-Da Yu & Yi-Zhou Jiang & Zhi-Ming Shao & Gen-Hong Di, 2014. "The Effect of Laterality and Primary Tumor Site on Cancer-Specific Mortality in Breast Cancer: A SEER Population-Based Study," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-8, April.
    • Handle: RePEc:plo:pone00:0094815
    DOI: 10.1371/journal.pone.0094815
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