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Prognostic Significance of Cyclin D1 Expression in Colorectal Cancer: A Meta-Analysis of Observational Studies

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  • Yang Li
  • Jun Wei
  • Chuanhui Xu
  • Zhongxin Zhao
  • Tiangeng You

Abstract

Objective: Cyclin D1 plays a vital role in cancer cell cycle progression and is overexpressed in many human cancers, including colorectal cancer (CRC). However, the prognostic value of cyclin D1 overexpression in colorectal cancer is conflicting and heterogeneous. We conducted a meta-analysis to more precisely evaluate its prognostic significance. Methods: A comprehensive literature search for relevant studies published up to January 2014 was performed using PubMed, EMBASE, and ISI Web of Science. The pooled hazard ratio (HR) with 95% confidence intervals (CI) was used to estimate the effects. Results: 22 studies with 4150 CRC patients were selected to evaluate the association between cyclin D1 and overall survival (OS), disease-free survival (DFS) and clinicopathological parameters. In a random-effects model, the results showed that cyclin D1 overexpression in CRC was significantly associated with both poor OS (HR = 0.73, 95% CI: 0.63–0.85, P

Suggested Citation

  • Yang Li & Jun Wei & Chuanhui Xu & Zhongxin Zhao & Tiangeng You, 2014. "Prognostic Significance of Cyclin D1 Expression in Colorectal Cancer: A Meta-Analysis of Observational Studies," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-14, April.
    • Handle: RePEc:plo:pone00:0094508
    DOI: 10.1371/journal.pone.0094508
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