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Quantitative Assessment of the Effect of KCNJ11 Gene Polymorphism on the Risk of Type 2 Diabetes

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  • Ling Qiu
  • Risu Na
  • Rong Xu
  • Siyang Wang
  • Hongguang Sheng
  • Wanling Wu
  • Yi Qu

Abstract

To clarify the role of potassium inwardly-rectifying-channel, subfamily-J, member 11 (KCNJ11) variation in susceptibility to type 2 diabetes (T2D), we performed a systematic meta-analysis to investigate the association between the KCNJ11 E23K polymorphism (rs5219) and the T2D in different genetic models. Databases including PubMed, Medline, EMBASE, and ISI Web of Science were searched to identify relevant studies. A total of 48 published studies involving 56,349 T2D cases, 81,800 controls, and 483 family trios were included in this meta-analysis. Overall, the E23K polymorphism was significantly associated with increased T2D risk with per-allele odds ratio (OR) of 1.12 (95% CI: 1.09–1.16; P

Suggested Citation

  • Ling Qiu & Risu Na & Rong Xu & Siyang Wang & Hongguang Sheng & Wanling Wu & Yi Qu, 2014. "Quantitative Assessment of the Effect of KCNJ11 Gene Polymorphism on the Risk of Type 2 Diabetes," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-9, April.
    • Handle: RePEc:plo:pone00:0093961
    DOI: 10.1371/journal.pone.0093961
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    1. Chloe Y Y Cheung & Annette W K Tso & Bernard M Y Cheung & Aimin Xu & Carol H Y Fong & K L Ong & Lawrence S C Law & Nelson M S Wat & Edward D Janus & Pak C Sham & Karen S L Lam, 2011. "The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study," PLOS ONE, Public Library of Science, vol. 6(12), pages 1-7, December.
    2. Yan-yan Li & Zhi-jian Yang & Chuan-wei Zhou & Xiang-ming Wang & Yun Qian & Jian Xu & Bei Wang & Jun Wu, 2013. "Adiponectin-11377CG Gene Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis of 6425 Subjects," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-10, April.
    3. Graeme I. Bell & Kenneth S. Polonsky, 2001. "Diabetes mellitus and genetically programmed defects in β-cell function," Nature, Nature, vol. 414(6865), pages 788-791, December.
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