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Pallidal Index as Biomarker of Manganese Brain Accumulation and Associated with Manganese Levels in Blood: A Meta-Analysis

Author

Listed:
  • Shao-Jun Li
  • Li Jiang
  • Xue Fu
  • Shuang Huang
  • Yan-Ni Huang
  • Xiang-Rong Li
  • Jing-Wen Chen
  • Yong Li
  • Hai-Lan Luo
  • Fang Wang
  • Shi-Yan Ou
  • Yue-Ming Jiang

Abstract

Objective: The current study was designed to evaluate the sensitivity, feasibility, and effectiveness of the pallidal index (PI) serving as a biomarker of brain manganese (Mn) accumulation, which would be used as an early diagnosis criteria for Mn neurotoxicity. Methods: The weighted mean difference (WMD) of the PI between control and Mn-exposed groups was estimated by using a random-effects or fixed-effects meta-analysis with 95% confidence interval (CI) performed by STATA software version 12.1. Moreover, the R package “metacor” was used to estimate correlation coefficients between PI and blood Mn (MnB). Results: A total of eight studies with 281 occupationally Mn-exposed workers met the inclusion criteria. Results were pooled and performed with the Meta-analysis. Our data indicated that the PI of the exposed group was significantly higher than that of the control (WMD: 7.76; 95% CI: 4.86, 10.65; I2 = 85.7%, p

Suggested Citation

  • Shao-Jun Li & Li Jiang & Xue Fu & Shuang Huang & Yan-Ni Huang & Xiang-Rong Li & Jing-Wen Chen & Yong Li & Hai-Lan Luo & Fang Wang & Shi-Yan Ou & Yue-Ming Jiang, 2014. "Pallidal Index as Biomarker of Manganese Brain Accumulation and Associated with Manganese Levels in Blood: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0093900
    DOI: 10.1371/journal.pone.0093900
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