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Long-Term Oral Feeding of Lutein-Fortified Milk Increases Voluntary Running Distance in Rats

Author

Listed:
  • Megumi Matsumoto
  • Masahito Hagio
  • Ryo Inoue
  • Tomohiro Mitani
  • Masako Yajima
  • Hiroshi Hara
  • Takaji Yajima

Abstract

To evaluate the effects of lutein-fortified milk administration on running exercise, a voluntary wheel-running model was performed in rats. Four-week-old F344 rats were administered test milk (10 mL/kg) daily following a 4-h fasting period, and their running distances were measured each day for a 9-week period. Total weekly running distance significantly increased from the sixth week until the end of the test period in lutein-supplemented rats (lutein-fortified milk administered) compared with control rats (vehicle administered). This increase was not apparent in rats administered lutein alone. In the lutein-fortified-milk exercise group compared with the sedentary control group, carnitine palitroyltransferase 1 (CPT-1), total AMP-activated protein kinase (tAMPK), and phosphorylated AMP-activated protein kinase (pAMPK) contents were significantly increased in the gastrocnemius muscle, with a concomitant decrease in triglyceride and total cholesterol levels in the blood and liver. Furthermore, the lutein level in blood of lutein-administered rats significantly decreased with exercise. These results suggest that lutein-fortified milk may enhance the effect of exercise by effective utilization of lipids when combined with voluntary running.

Suggested Citation

  • Megumi Matsumoto & Masahito Hagio & Ryo Inoue & Tomohiro Mitani & Masako Yajima & Hiroshi Hara & Takaji Yajima, 2014. "Long-Term Oral Feeding of Lutein-Fortified Milk Increases Voluntary Running Distance in Rats," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-8, April.
    • Handle: RePEc:plo:pone00:0093529
    DOI: 10.1371/journal.pone.0093529
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