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Hepatic Arterial Infusion Chemotherapy for Patients with Huge Unresectable Hepatocellular Carcinoma

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Listed:
  • Wei-Lun Tsai
  • Kwok-Hung Lai
  • Huei-Lung Liang
  • Ping-I Hsu
  • Hoi-Hung Chan
  • Wen-Chi Chen
  • Hsien-Chung Yu
  • Feng-Woei Tsay
  • Huay-Min Wang
  • Hung-Chih Tsai
  • Jin-Shiung Cheng

Abstract

Background and Aim: The optimal treatment for huge unresectable hepatocellular carcinoma (HCC) remains controversial. The outcome of transcatheter arterial chemoembolization (TACE) for patients huge unresectable HCC is generally poor and the survival benefit of TACE in these patients is unclear. The aim of the study is to compare the effect of hepatic arterial infusion chemotherapy (HAIC) versus symptomatic treatment in patients with huge unresectable HCC. Methods: Since 2000 to 2005, patients with huge (size >8cm) unresectable HCC were enrolled. Fifty-eight patients received HAIC and 44 patients received symptomatic treatment. In the HAIC group, each patient received 2.4+1.4 (range: 1–6) courses of HAIC. Baseline characteristics and survival were compared between the HAIC and symptomatic treatment groups. Results: The HAIC group and the symptomatic treatment group were similar in baseline characteristics and tumor stages. The overall survival rates at one and two years were 29% and 14% in the HAIC group and 7% and 5% in the symptomatic treatment group, respectively. The patients in the HAIC group had significantly better overall survival than the symptomatic treatment group (P

Suggested Citation

  • Wei-Lun Tsai & Kwok-Hung Lai & Huei-Lung Liang & Ping-I Hsu & Hoi-Hung Chan & Wen-Chi Chen & Hsien-Chung Yu & Feng-Woei Tsay & Huay-Min Wang & Hung-Chih Tsai & Jin-Shiung Cheng, 2014. "Hepatic Arterial Infusion Chemotherapy for Patients with Huge Unresectable Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-5, May.
    • Handle: RePEc:plo:pone00:0092784
    DOI: 10.1371/journal.pone.0092784
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