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Mathematical Modeling of Calcium Waves Induced by Mechanical Stimulation in Keratinocytes

Author

Listed:
  • Yasuaki Kobayashi
  • Yumi Sanno
  • Akihiko Sakai
  • Yusuke Sawabu
  • Moe Tsutsumi
  • Makiko Goto
  • Hiroyuki Kitahata
  • Satoshi Nakata
  • Junichi Kumamoto
  • Mitsuhiro Denda
  • Masaharu Nagayama

Abstract

Recent studies have shown that the behavior of calcium in the epidermis is closely related to the conditions of the skin, especially the differentiation of the epidermal keratinocytes and the permeability barrier function, and therefore a correct understanding of the calcium dynamics is important in explaining epidermal homeostasis. Here we report on experimental observations of in vitro calcium waves in keratinocytes induced by mechanical stimulation, and present a mathematical model that can describe the experimentally observed wave behavior that includes finite-range wave propagation and a ring-shaped pattern. A mechanism of the ring formation hypothesized by our model may be related to similar calcium propagation patterns observed during the wound healing process in the epidermis. We discuss a possible extension of our model that may serve as a tool for investigating the mechanisms of various skin diseases.

Suggested Citation

  • Yasuaki Kobayashi & Yumi Sanno & Akihiko Sakai & Yusuke Sawabu & Moe Tsutsumi & Makiko Goto & Hiroyuki Kitahata & Satoshi Nakata & Junichi Kumamoto & Mitsuhiro Denda & Masaharu Nagayama, 2014. "Mathematical Modeling of Calcium Waves Induced by Mechanical Stimulation in Keratinocytes," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-10, March.
    • Handle: RePEc:plo:pone00:0092650
    DOI: 10.1371/journal.pone.0092650
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