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Anti-Cyclic Citrullinated Peptide Antibody Is Associated with Interstitial Lung Disease in Patients with Rheumatoid Arthritis

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Listed:
  • Yufeng Yin
  • Di Liang
  • Lidan Zhao
  • Yang Li
  • Wei Liu
  • Yan Ren
  • Yongzhe Li
  • Xiaofeng Zeng
  • Fengchun Zhang
  • Fulin Tang
  • Guangliang Shan
  • Xuan Zhang

Abstract

Objective: Patients with rheumatoid arthritis (RA) are at risk to develop RA-associated interstitial lung disease (RA-ILD). This retrospective study aimed to investigate the potential association of the positivity of serum anti-cyclic citrullinated peptide antibody (anti-CCP2) and rheumatoid factor (RF) with RA-ILD in RA patients. Methods: A total of 285 RA patients were recruited at the inpatient service of Peking Union Medical College Hospital in China between 2004 and 2013. Individual patients were evaluated for the evidence of ILD. The concentrations of serum anti-CCP2 and RF in individual patients were measured. The potential risk factors for ILD in RA patients were assessed by univariate and multivariate models. Results: There were 71 RA patients with RA-ILD, accounting for 24.9% in this population. The positive rates of anti-CCP2 and RF in the patients with RA-ILD were significantly higher than that in the patients with RA-only (88.7% vs. 67.3%, p

Suggested Citation

  • Yufeng Yin & Di Liang & Lidan Zhao & Yang Li & Wei Liu & Yan Ren & Yongzhe Li & Xiaofeng Zeng & Fengchun Zhang & Fulin Tang & Guangliang Shan & Xuan Zhang, 2014. "Anti-Cyclic Citrullinated Peptide Antibody Is Associated with Interstitial Lung Disease in Patients with Rheumatoid Arthritis," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-6, April.
    • Handle: RePEc:plo:pone00:0092449
    DOI: 10.1371/journal.pone.0092449
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