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Consistency of Safety and Efficacy of New Oral Anticoagulants across Subgroups of Patients with Atrial Fibrillation

Author

Listed:
  • Jean-Christophe Lega
  • Laurent Bertoletti
  • Cyrielle Gremillet
  • Céline Chapelle
  • Patrick Mismetti
  • Michel Cucherat
  • Denis Vital-Durand
  • Silvy Laporte
  • on behalf of The Meta-Embol Group

Abstract

Aims: The well-known limitations of vitamin K antagonists (VKA) led to development of new oral anticoagulants (NOAC) in non-valvular atrial fibrillation (NVAF). The aim of this meta-analysis was to determine the consistency of treatment effects of NOAC irrespective of age, comorbidities, or prior VKA exposure. Methods and Results: All randomized, controlled phase III trials comparing NOAC to VKA up to October 2012 were eligible provided their results (stroke/systemic embolism (SSE) and major bleeding (MB)) were reported according to age (≤ or >75 years), renal function, CHADS2 score, presence of diabetes mellitus or heart failure, prior VKA use or previous cerebrovascular events. Interactions were considered significant at p

Suggested Citation

  • Jean-Christophe Lega & Laurent Bertoletti & Cyrielle Gremillet & Céline Chapelle & Patrick Mismetti & Michel Cucherat & Denis Vital-Durand & Silvy Laporte & on behalf of The Meta-Embol Group, 2014. "Consistency of Safety and Efficacy of New Oral Anticoagulants across Subgroups of Patients with Atrial Fibrillation," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-9, March.
    • Handle: RePEc:plo:pone00:0091398
    DOI: 10.1371/journal.pone.0091398
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