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Risk Factors for Cervical Intraepithelial Neoplasia in HIV-Infected Women on Antiretroviral Treatment in Côte d'Ivoire, West Africa

Author

Listed:
  • Antoine Jaquet
  • Apollinaire Horo
  • Didier K Ekouevi
  • Badian Toure
  • Patrick A Coffie
  • Benjamin Effi
  • Severin Lenaud
  • Eugene Messou
  • Albert Minga
  • Annie J Sasco
  • François Dabis
  • the IeDEA West Africa Collaboration

Abstract

Background: Facing the dual burden of invasive cervical cancer and HIV in sub-Saharan Africa, the identification of preventable determinants of Cervical Intraepithelial Neoplasia (CIN) in HIV-infected women is of paramount importance. Methods: A cervical cancer screening based on visual inspection methods was proposed to HIV-infected women in care in Abidjan, Côte d'Ivoire. Positively screened women were referred for a colposcopy to a gynaecologist who performed directed biopsies. Results: Of the 2,998 HIV-infected women enrolled, 132 (4.4%) CIN of any grade (CIN+) were identified. Women had been followed-up for a median duration of three years [IQR: 1–5] and 76% were on antiretroviral treatment (ART). Their median most recent CD4 count was 452 [IQR: 301–621] cells/mm3. In multivariate analysis, CIN+ was associated with a most recent CD4 count >350 cells/mm3 (OR: 0.3; 95% CI: 0.2–0.6) or ≥200–350 cells/mm3 (OR 0.6; 95% CI 0.4–1.0) (Ref:

Suggested Citation

  • Antoine Jaquet & Apollinaire Horo & Didier K Ekouevi & Badian Toure & Patrick A Coffie & Benjamin Effi & Severin Lenaud & Eugene Messou & Albert Minga & Annie J Sasco & François Dabis & the IeDEA West, 2014. "Risk Factors for Cervical Intraepithelial Neoplasia in HIV-Infected Women on Antiretroviral Treatment in Côte d'Ivoire, West Africa," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-8, March.
    • Handle: RePEc:plo:pone00:0090625
    DOI: 10.1371/journal.pone.0090625
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