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Effects of Beta-Blockers on Heart Failure with Preserved Ejection Fraction: A Meta-Analysis

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  • Feng Liu
  • Yanmei Chen
  • Xuguang Feng
  • Zhonghua Teng
  • Ye Yuan
  • Jianping Bin

Abstract

Background: Effects of beta-blockers on the prognosis of the heart failure patients with preserved ejection fraction (HFpEF) remain controversial. The aim of this meta-analysis was to determine the impact of beta-blockers on mortality and hospitalization in the patients with HFpEF. Methods: A search of MEDLINE, EMBASE, and the Cochrane Library databases from 2005 to June 2013 was conducted. Clinical studies reporting outcomes of mortality and/or hospitalization for patients with HFpEF (EF ≥ 40%), being assigned to beta-blockers treatment and non-beta-blockers control group were included. Results: A total of 12 clinical studies (2 randomized controlled trials and 10 observational studies) involving 21,206 HFpEF patients were included for this meta-analysis. The pooled analysis demonstrated that beta-blocker exposure was associated with a 9% reduction in relative risk for all-cause mortality in patients with HFpEF (95% CI: 0.87 – 0.95; P

Suggested Citation

  • Feng Liu & Yanmei Chen & Xuguang Feng & Zhonghua Teng & Ye Yuan & Jianping Bin, 2014. "Effects of Beta-Blockers on Heart Failure with Preserved Ejection Fraction: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-11, March.
    • Handle: RePEc:plo:pone00:0090555
    DOI: 10.1371/journal.pone.0090555
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